Neubert R, Fahr F, Mäder C, Lücke L, Fries G, Rostock G
Department of Pharmacy, Martin-Luther-University, Halle/Saale, Fed. Rep. of Germany.
Arzneimittelforschung. 1992 Sep;42(9):1098-100.
It is shown that it is possible to characterize sustained release formulations in vitro using not only dissolution data but also an absorption model system. The mean dissolution time (MDT) has been shown to be a suitable parameter for evaluating sustained release formulations in vitro. t1/2 and mean residence time (MRT) have been shown to be convenient pharmacokinetic parameters for characterizing sustained release formulations. For comparing in vitro and in vivo results the quotients MDT normal/MDT retard and MRT normal/MRT retard do seem to be useful.
结果表明，不仅可以使用溶出数据，还可以使用吸收模型系统在体外对缓释制剂进行表征。平均溶出时间（MDT）已被证明是体外评估缓释制剂的合适参数。t1/2和平均驻留时间（MRT）已被证明是表征缓释制剂方便的药代动力学参数。为了比较体外和体内结果，MDT正常/MDT缓释和MRT正常/MRT缓释的商似乎是有用的。
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