Mamolo M G, Vio L, Furlan G
Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia Università degli Studi, Trieste, Italia.
Farmaco. 1992 Jul-Aug;47(7-8):1067-80.
A rapid, sensitive and specific reversed phase HPLC method for the simultaneous assay of amiodarone and its major metabolite desethylamiodarone in human serum has been developed. This method is suitable for pharmacokinetic studies and for monitoring of the drug and metabolite concentrations in serum of patients on both short and long-term therapy with amiodarone.
已开发出一种快速、灵敏且特异的反相高效液相色谱法，用于同时测定人血清中的胺碘酮及其主要代谢产物去乙基胺碘酮。该方法适用于药代动力学研究，以及监测接受胺碘酮短期和长期治疗患者血清中的药物和代谢物浓度。
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