Trabandt A, Gay R E, Gay S
Department of Medicine, Research Center Borstel, Germany.
APMIS. 1992 Oct;100(10):861-75. doi: 10.1111/j.1699-0463.1992.tb04012.x.
Rheumatoid arthritis (RA) is a chronic systemic disorder that is dominated by the debilitating sequelae associated with the progressive destruction of articular joints. The molecular and cellular basis of rheumatoid joint destruction is characterized by an abnormal expression of oncogenes modulating cellular proliferation and the induction of lysosomal and metalloproteinases. Based on the observation that the synovial hyperplasia in RA is associated with the proliferation of transformed-appearing synovial lining cells and an overexpression of such oncogenes, the possibility that a hitherto unknown HTLV related retrovirus is involved in the etiopathogenesis of RA is discussed.
类风湿性关节炎（RA）是一种慢性全身性疾病，其特征是与关节渐进性破坏相关的使人衰弱的后遗症。类风湿性关节破坏的分子和细胞基础表现为调节细胞增殖的癌基因异常表达以及溶酶体和金属蛋白酶的诱导。基于类风湿性关节炎滑膜增生与形态异常的滑膜衬里细胞增殖及此类癌基因过度表达相关的观察结果，讨论了一种迄今未知的与人类嗜T淋巴细胞病毒（HTLV）相关的逆转录病毒参与类风湿性关节炎发病机制的可能性。
