Ibebunjo C, Kamalu B P, Ihemelandu E C
Department of Veterinary Surgery and Obstetrics, Faculty of Veterinary Medicine, University of Nigeria, Nsukka.
Br J Nutr. 1992 Sep;68(2):483-91. doi: 10.1079/bjn19920106.
Effects of cassava (Manihot esculenta Crantz)-borne organic cyanide and inorganic cyanide in the form of sodium cyanide on bone and muscle development were investigated in eighteen dogs of Nigerian breed. After 16 weeks of stabilization in the laboratory from the time of purchase when the dogs were fed on the same diet, they were randomly assigned to three experimental groups of six dogs each. The control group was fed on rice while the other two groups were fed on either cassava (gari) or rice plus cyanide. The three diets were made isoenergetic and isonitrogenous by varying the quantity of meat incorporated into them. The results obtained after 14 weeks of feeding the respective diets indicated that there was retardation of muscle development in the gari-fed dogs. This may have resulted from gluconeogenesis from muscle protein associated with suppression of production of insulin by the pancreas in this group. The results indicated also that the effects of inorganic dietary cyanides on muscle development were different. Both forms of dietary cyanides, however, had no adverse effect on bone development.
以木薯（Manihot esculenta Crantz）中的有机氰化物和氰化钠形式的无机氰化物对尼日利亚品种的18只犬骨骼和肌肉发育的影响进行了研究。从购买时起在实验室稳定饲养16周后，这些犬喂食相同的饮食，然后将它们随机分为三个实验组，每组6只犬。对照组喂食大米，另外两组分别喂食木薯（加里）或大米加氰化物。通过改变每种饮食中添加的肉量，使三种饮食的能量和氮含量相等。在分别喂食各自饮食14周后获得的结果表明，喂食加里的犬肌肉发育迟缓。这可能是由于该组中与胰腺胰岛素分泌受抑制相关的肌肉蛋白糖异生所致。结果还表明，饮食中的无机氰化物对肌肉发育的影响不同。然而，两种形式的饮食氰化物对骨骼发育均无不良影响。
