季铵化合物与长链脂肪酸的混合物作为抗真菌剂。

Mixturs of quaternary ammonium compounds and long-chain fatty acids as antifungal agents.

作者信息

KULL F C, EISMAN P C, SYLWESTROWICZ H D, MAYER R L

出版信息

Appl Microbiol. 1961 Nov;9(6):538-41. doi: 10.1128/am.9.6.538-541.1961.

DOI:10.1128/am.9.6.538-541.1961

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1057783/

Abstract

The influence of undecylenic acid on the fungistatic effect of phenoxyethyldimethyldodecylammonium bromide (Domiphen bromide) against Trichophyton mentagrophytes was investigated. The unsaturated fatty acid was found to enhance the fungistatic activity of Domiphen bromide against this organism. The ratio of concentrations of these agents has a marked influence on the results of in vitro tests for antifungal action resulting in a completely different effect than heretofore noted in combination experiments against bacteria. The enhancing phenomenon is not particular to T. mentagrophytes, it was observed also with Candida albicans.

摘要

研究了十一烯酸对苯氧乙基二甲基十二烷基溴化铵（度米芬）抗须癣毛癣菌抑菌作用的影响。发现这种不饱和脂肪酸可增强度米芬对该菌的抑菌活性。这些药剂浓度的比例对体外抗真菌作用试验结果有显著影响，导致与以往针对细菌的联合实验中所观察到的结果完全不同的效应。这种增强现象并非须癣毛癣菌所特有，在白色念珠菌中也观察到了。

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