LAW L W
Bull World Health Organ. 1962;26(5):607-12.
A critical review is made of the present knowledge of the etiology of neoplasms of the haematopoietic system in experimental animals and man. Genetic factors play a dominant role in the origin of leukaemias in mice. A Mendelian interpretation of the data is excluded and several genes appear to be involved in susceptibility. The data available on leukaemias in man are equivocal so far as the role of genetic factors is involved. The author discusses the value of family and twin studies-which suggest the operation of rare, highly penetrant, recessive genes-and of cytogenetic studies in contributing to a fuller understanding of the nature and etiology of leukaemia.
对实验动物和人类造血系统肿瘤病因的现有知识进行了批判性综述。遗传因素在小鼠白血病的发生中起主导作用。孟德尔对数据的解释被排除,似乎有几个基因与易感性有关。就遗传因素的作用而言,目前关于人类白血病的数据尚不明确。作者讨论了家族研究和双胞胎研究(提示存在罕见、高外显率的隐性基因)以及细胞遗传学研究在更全面理解白血病的性质和病因方面的价值。