干扰素介导的细胞内信号传导。伯基特淋巴瘤细胞中不同磷脂酶活性的调节。
Interferon-mediated intracellular signalling. Modulation of different phospholipase activities in Burkitt lymphoma cells.
作者信息
Cataldi A, Rana R, di Primio R, Bareggi R, Lisio R, Toto N, Miscia S
机构信息
Istituto di Morfologia Umana Normale, Università di Chieti, Italy.
出版信息
FEBS Lett. 1992 Nov 30;313(3):210-2. doi: 10.1016/0014-5793(92)81193-p.
The effect of interferon-alpha on Daudi lymphoma cells either sensitive or resistant to the action of this cytokine has been analysed in terms of phospholipase C (PLC) and D (PLD) activities. Results have shown a combined modulation of PIP2-specific phospholipase C and phospholipase D. In particular, a decreased activity of PIP2-specific PLC has been found, concomitant to a PLD-mediated phosphatidylcholine hydrolysis, suggesting that the intracellular signalling activated by interferon in Daudi cells involves a phospholipase D/phosphohydrolase pathway.
已根据磷脂酶C（PLC）和磷脂酶D（PLD）活性分析了α干扰素对达乌迪淋巴瘤细胞（对这种细胞因子的作用敏感或耐药）的影响。结果显示了对磷脂酰肌醇-4,5-二磷酸特异性磷脂酶C和磷脂酶D的联合调节。具体而言，已发现磷脂酰肌醇-4,5-二磷酸特异性PLC的活性降低，同时伴有PLD介导的磷脂酰胆碱水解，这表明干扰素在达乌迪细胞中激活的细胞内信号传导涉及磷脂酶D/磷酸水解酶途径。
Zotero 插件