吡罗昔康引起肝脏亚大块坏死。

Paterson D, Kerlin P, Walker N, Lynch S, Strong R

Department of Gastroenterology and Hepatology, Brisbane, Australia.

Gut. 1992 Oct;33(10):1436-8. doi: 10.1136/gut.33.10.1436.

Several widely used non-steroidal anti-inflammatory drugs have been reported as causing severe hepatitis. Three cases of severe acute hepatitis have been reported in association with piroxicam. A fatal submassive necrosis that occurred in a 68 year old lady who had received piroxicam for 15 months is described. A 48 year old man who developed submassive hepatic necrosis six weeks after beginning piroxicam but was successfully treated with orthotopic liver transplantation is also reported. Piroxicam may induce submassive necrosis of the liver, probably as an idiosyncratic reaction.

据报道，几种广泛使用的非甾体抗炎药可导致严重肝炎。已有3例严重急性肝炎与吡罗昔康有关的报道。本文描述了一名68岁女性在服用吡罗昔康15个月后发生的致命性亚大块坏死。还报道了一名48岁男性，在开始服用吡罗昔康六周后发生亚大块肝坏死，但经原位肝移植成功治愈。吡罗昔康可能诱发肝脏亚大块坏死，这可能是一种特异反应。