Chazan R, Tadeusiak W, Jaworski A, Droszcz W
Department of Pneumology, Warsaw University Medical School, Poland.
Int J Clin Pharmacol Ther Toxicol. 1992 Oct;30(10):371-3.
The effect of salbutamol, a selective beta 2-adrenergic agonist, on creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) activity in serum of 20 asthmatic patients was investigated. Venous blood was obtained 30 min, 2 h and 4 h after 0.5 mg salbutamol intravenous injection of 0.5 mg salbutamol. Total creatine kinase activity was assayed on a Technico RA-1000 analyzer with the IFCC recommended method. CK-MB activity was determined using a centrifugal analyzer (Cobas Fera, Roche, Switzerland). Reagent kits were provided by Boehringer Mannheim (FRG). We observed no increase of CK-activity after salbutamol, and found a statistically significant increase of CK-MB activity. Serum CK-MB activity before treatment was 13 +/- 10/IU/l after 30 minutes drug, 31.8 +/- 19 IU/l after 2 h 27.2 +/- 17.79 and after 4 h 22.6 +/- 12 IU/l. We conclude that salbutamol exerts a cardiotoxic effect.
研究了选择性β2-肾上腺素能激动剂沙丁胺醇对20例哮喘患者血清肌酸激酶（CK）和肌酸激酶同工酶（CK-MB）活性的影响。在静脉注射0.5mg沙丁胺醇后30分钟、2小时和4小时采集静脉血。总肌酸激酶活性采用Technico RA-1000分析仪，按照国际临床化学联合会（IFCC）推荐的方法进行测定。CK-MB活性使用离心分析仪（瑞士罗氏公司的Cobas Fera）进行测定。试剂试剂盒由德国宝灵曼公司提供。我们观察到沙丁胺醇给药后CK活性未增加，但发现CK-MB活性有统计学意义的增加。治疗前血清CK-MB活性为13±10IU/L，用药30分钟后为31.8±19IU/L，2小时后为27.2±17.79IU/L，4小时后为22.6±12IU/L。我们得出结论，沙丁胺醇具有心脏毒性作用。
