Markiewicz A, Tausz B, Zahorska-Markiewicz B, Nawrot J
District Railway Hospital, Katowice, Poland.
Int J Clin Pharmacol Ther Toxicol. 1992 Oct;30(10):400-4.
Calcium heparin in a dose of 13,200-15,300 U was administered in 8 healthy men, aged 26-54, by inhalation at 8:00 or 20:00, where each study was separated by a minimum of three weeks interval. Serum coagulation variables, lipids, electrolytes and enzymes were measured before inhalation, 2 h later and after 48 h. Following heparin inhalation changes both in coagulation variables and less distinct in lipids variables were noted at both test times, but no morning-evening differences were observed, with the exception of cholesterol and HDL.
对8名年龄在26至54岁之间的健康男性，于上午8点或晚上8点通过吸入方式给予剂量为13,200 - 15,300单位的肝素钙，每项研究之间至少间隔三周。在吸入前、2小时后以及48小时后测量血清凝血变量、脂质、电解质和酶。吸入肝素后，在两个测试时间点均观察到凝血变量发生变化，脂质变量变化不太明显，但除胆固醇和高密度脂蛋白外，未观察到早晚差异。
