合成型鲍曼-伯克环的设计及其抑制特性
Design and inhibitory properties of synthetic Bowman-Birk loops.
作者信息
Maeder D L, Sunde M, Botes D P
机构信息
Department of Biochemistry, University of Cape Town, Rondebosch, Republic of South Africa.
出版信息
Int J Pept Protein Res. 1992 Aug;40(2):97-102. doi: 10.1111/j.1399-3011.1992.tb01455.x.
Abstract
A cyclic tridecapeptide based on the sequence of an anti-tryptic loop of a Bowman-Birk inhibitor was synthesized, and demonstrated to be active as an inhibitor of trypsin. Molecular modeling of this sequence suggested an improved sequence which demonstrated an order of magnitude improvement in the inhibitory constant.
摘要
基于鲍曼-伯克抑制剂抗胰蛋白酶环序列合成了一种环状十三肽，并证明其作为胰蛋白酶抑制剂具有活性。该序列的分子模拟提出了一种改进序列，其抑制常数提高了一个数量级。
Zotero 插件