Changes of rabbit platelet function following simultaneous administration of Ticlopidine hydrochloride and Argipidine (MD-805).

Ticlopidine hydrochloride and Argipidine were administered simultaneously to rabbits and the changes in platelet function and coagulation-fibrinolysis were determined. Ticlopidine hydrochloride and Argipidine did not give rise to an additive or synergistic effect on the ADP-induced platelet aggregation. However, simultaneous administration of Argipidine and Ticlopidine hydrochloride significantly inhibited the collagen-induced platelet aggregation, as compared to the effect of single administration of Ticlopidine hydrochloride at 60 min after intravenous administration of Argipidine. Furthermore, at 90 min after the intravenous administration, the PAF-induced platelet aggregation in the simultaneous administration was significantly different from that in each individual administration. These results suggested that the effect of simultaneous administration on the platelet aggregation was dependent largely on the effect of Ticlopidine hydrochloride alone.