Gratama J W, Meuzelaar J J, Dalinghaus M, Koers J H, Gratama S, Zijlstra W G, Kuipers J R
Department of Pediatrics, University of Groningen, The Netherlands.
J Appl Physiol (1985). 1992 Oct;73(4):1542-8. doi: 10.1152/jappl.1992.73.4.1542.
We studied regional blood flows with radioactive-labeled microspheres in 12 7-wk-old lambs with an aortopulmonary left-to-right shunt [59 +/- 3% (SE) of left ventricular (LV) output] and in 11 control lambs, at rest and during exercise at 80% of predetermined peak O2 consumption. At rest, systemic blood flow was similar in the two groups. Blood flow to the heart and diaphragm was substantially higher in the shunt than in the control lambs. Blood flow to the other organs was not significantly different between the two groups. During exercise, systemic blood flow increased substantially but less in shunt (81%) than in control lambs (134%). Blood flow to the heart and diaphragm increased, that to the heart still being higher in shunt than in control lambs. Blood flow to the brain did not change, whereas that to the kidneys and splanchnic organs decreased to the same extent (25%) in shunt and control lambs. Intrahepatic and intrarenal blood flow redistribution in the shunt lambs persisted during exercise. In conclusion, myocardial blood flow is not increased at the expense of one particular organ, nor is it associated with an essential change in exercise-induced redistribution in shunt lambs.
我们使用放射性标记微球研究了12只7周龄患有主肺动脉左向右分流（占左心室输出量的59±3%[标准误]）的羔羊和11只对照羔羊在静息状态以及在预定峰值耗氧量80%的运动状态下的局部血流情况。静息时，两组的全身血流量相似。分流组羔羊心脏和膈肌的血流量显著高于对照组。两组其他器官的血流量无显著差异。运动时，全身血流量大幅增加，但分流组增加幅度（81%）小于对照羔羊（134%）。心脏和膈肌的血流量增加，分流组心脏的血流量仍高于对照羔羊。脑血流量未改变，而分流组和对照羔羊肾脏及内脏器官的血流量下降程度相同（25%）。分流组羔羊肝内和肾内血流再分布在运动过程中持续存在。总之，分流组羔羊心肌血流量增加并非以牺牲某一特定器官为代价，也与运动诱导的血流再分布的本质变化无关。
