Dahl H
Acta Pathol Microbiol Scand B. 1977 Feb;85B(1):54-60.
Human leukocyte interferon (IF) inhibits the growth rate of homologous cells in culture. The growth inhibitory component, formerly separated from the antiviral component of human leukocyte IF by adsorption chromatography on albumin-agarose, is investigated. The properties of the component are compared with the accepted characteristics of IF. The growth inhibition is caused by a small molecule, unstable to pH 2 treatment with HCl, but stable to trichloro-acetic acid (TCA) and to proteolytic enzymes. The siolated growth inhibitor seems to be a dimer of molecular weight (mol wt.) approximately 2300. It is activated by heat treatment and lacks species specificity. The discrepancies in the properties of the growth inhibitor before and after separation from IF are discussed.
人白细胞干扰素（IF）可抑制培养中同源细胞的生长速率。对以前通过白蛋白 - 琼脂糖吸附色谱从人白细胞IF的抗病毒成分中分离出来的生长抑制成分进行了研究。将该成分的特性与IF公认的特性进行了比较。生长抑制是由一种小分子引起的，该小分子对用HCl进行pH 2处理不稳定，但对三氯乙酸（TCA）和蛋白水解酶稳定。分离出的生长抑制剂似乎是一种分子量（mol wt.）约为2300的二聚体。它可通过热处理激活且缺乏种属特异性。讨论了从IF分离前后生长抑制剂特性的差异。
