Asada K, Ogushi F, Tani K, Kawaji K, Nakahira S, Yasuoka S, Ogura T
Third Department of Internal Medicine, School of Medicine, Tokushima University, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Sep;30(9):1682-6.
Carbohydrate antigen 19-9 (CA19-9) was measured in bronchial lavage fluid in 21 patients with lung cancer and 4 patients with benign lung diseases (2 patients with DPB, 2 patients with BE). Bronchial lavage of the tumor-related bronchus was performed. In normal subjects, levels of CA19-9 in lavage fluid were less than 1000 IU/ml. On the other hand, in 6 patients with lung cancer, levels of CA19-9 were higher than 1000 IU/ml, and in 3 of these cases, CA19-9 levels were higher than 8000 IU/ml. All six three cases were histologically diagnosed as adenocarcinoma. Tumor resected at operation was then stained by antibody recognizing CA19-9. Tumor in cases with high levels of CA19-9 was stained immunohistochemically. These results indicate that measurement of CA19-9 in bronchial lavage fluid of the tumor-related bronchus is a useful auxiliary method in the diagnosis of lung cancer.
对21例肺癌患者和4例良性肺疾病患者（2例弥漫性泛细支气管炎患者、2例支气管炎患者）的支气管灌洗液进行了糖类抗原19-9（CA19-9）检测。对肿瘤相关支气管进行了支气管灌洗。在正常受试者中，灌洗液中CA19-9水平低于1000 IU/ml。另一方面，6例肺癌患者的CA19-9水平高于1000 IU/ml，其中3例CA19-9水平高于8000 IU/ml。这6例（原文此处有误，应是3例）均经组织学诊断为腺癌。然后用识别CA19-9的抗体对手术切除的肿瘤进行染色。CA19-9水平高的病例中的肿瘤进行了免疫组织化学染色。这些结果表明，检测肿瘤相关支气管的支气管灌洗液中的CA19-9是肺癌诊断中一种有用的辅助方法。
