Kurjak A, Schulman H, Sosic A, Zalud I, Shalan H
Ultrasonic Institute, Medical School, University of Zagreb, Croatia.
Obstet Gynecol. 1992 Dec;80(6):917-21.
One thousand postmenopausal women were examined prospectively with transvaginal ultrasound. Seven hundred forty-three (74%) were asymptomatic and presented for screening. Data were analyzed to determine the accuracy of this new modality. Eighty-three women had surgery, and 29 malignant neoplasms were found. Color flow was identified in 27 of 29 malignant tumors and 35% of benign masses. A cutoff value of 0.41 for the Doppler resistance index in the feeder vessels had the best discriminatory value; sensitivity and specificity were 96 and 95%, respectively, for separating benign from malignant neoplasms. Positive and negative predictive values were 96 and 95%, respectively. Morphology alone had poor sensitivity, but when combined with Doppler indices, the sensitivity improved to 90% and the positive and negative predictive values were 90 and 96%, respectively. The results of this study suggest that in the postmenopausal ovary, transvaginal B-mode imaging, color flow, and Doppler indices satisfy criteria as tests that may be sensitive and specific enough for application in a screening program.
对1000名绝经后女性进行了经阴道超声的前瞻性检查。其中743名(74%)无症状,前来进行筛查。对数据进行分析以确定这种新方法的准确性。83名女性接受了手术,发现了29例恶性肿瘤。29例恶性肿瘤中的27例以及35%的良性肿块中发现了血流信号。供血血管中多普勒阻力指数的截断值为0.41时具有最佳鉴别价值;区分良性和恶性肿瘤的敏感性和特异性分别为96%和95%。阳性和阴性预测值分别为96%和95%。单独的形态学敏感性较差,但与多普勒指数结合时,敏感性提高到90%,阳性和阴性预测值分别为90%和96%。本研究结果表明,在绝经后卵巢中,经阴道B超成像、血流信号和多普勒指数符合作为筛查项目中可能足够敏感和特异的检测方法的标准。