帕金森病老年患者体内维生素A、C和E的浓度。
Concentrations of vitamins A, C and E in elderly patients with Parkinson's disease.
作者信息
King D, Playfer J R, Roberts N B
机构信息
Department of Geriatric Medicine, Clatterbridge Hospital, Merseyside, UK.
出版信息
Postgrad Med J. 1992 Aug;68(802):634-7. doi: 10.1136/pgmj.68.802.634.
Concentrations of the naturally occurring antioxidant vitamins A, C and E were measured in 27 patients with Parkinson's disease and 16 age-matched control subjects, from a similarly disabled patient group. There was no significant difference in the serum concentrations of vitamins A and E in the two groups. Vitamin C was significantly higher (P < 0.05) in the Parkinson's disease group, however, the mean leucocyte vitamin C concentration in the control group was low (101 nmol/10(8) WBCS) compared to established data in healthy young individuals (119-301 nmol/10(8) WBCS). There was no correlation between the severity or duration of Parkinson's disease and concentrations of vitamins A, C and E. There is therefore no evidence from this study that a deficiency of these antioxidants contributes to the onset or progress of Parkinson's disease.
对27名帕金森病患者和16名年龄匹配的对照受试者（来自残疾情况相似的患者群体）的天然抗氧化维生素A、C和E浓度进行了测量。两组的维生素A和E血清浓度无显著差异。然而，帕金森病组的维生素C显著更高（P<0.05），但与健康年轻个体的既定数据（119 - 301 nmol/10⁸白细胞）相比，对照组的平均白细胞维生素C浓度较低（101 nmol/10⁸白细胞）。帕金森病的严重程度或病程与维生素A、C和E的浓度之间无相关性。因此，本研究没有证据表明这些抗氧化剂缺乏会导致帕金森病的发生或进展。
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