帕金森病患者脑脊液中α-生育酚（维生素E）水平

Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Parkinson's disease.

作者信息

Molina J A, de Bustos F, Jiménez-Jiménez F J, Benito-León J, Ortí-Pareja M, Gasalla T, Tallón-Barranco A, Navarro J A, Arenas J, Enríquez-de-Salamanca R

机构信息

Department of Neurology, Hospital Universitario Doce de Octubre, Alcala de Henares, Spain.

出版信息

J Neural Transm (Vienna). 1997;104(11-12):1287-93. doi: 10.1007/BF01294729.

DOI:10.1007/BF01294729

PMID:9503274

Abstract

We compared CSF and serum levels, and the CSF/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 34 patients with Parkinson's disease (PD) and 47 controls. CSF and serum vitamin E levels were correlate. The mean CSF and serum vitamin E levels, and the CSF/serum ratio of PD patients did not differ significantly between the groups. There was no influence of antiparkinsonian therapy on CSF vitamin E levels. CSF vitamin E levels did not correlate with age, age at onset, duration of the disease, scores of the Unified Parkinson Disease Rating Scale of the Hoehn and Yahr staging in the PD group. These results suggest that CSF vitamin E concentrations are unrelated with the risk for PD.

摘要

我们比较了34例帕金森病（PD）患者和47名对照者脑脊液（CSF）和血清中通过高效液相色谱法（HPLC）测定的α-生育酚（维生素E）水平以及CSF/血清比值。CSF和血清维生素E水平具有相关性。两组间PD患者的平均CSF和血清维生素E水平以及CSF/血清比值无显著差异。抗帕金森病治疗对CSF维生素E水平无影响。在PD组中，CSF维生素E水平与年龄、发病年龄、病程、统一帕金森病评定量表（Hoehn和Yahr分期）评分均无相关性。这些结果表明，CSF维生素E浓度与PD风险无关。