Köhler H, Nustede R, Lüdtke F E, Barthel M, Schafmayer A
Department of General Surgery, University of Göttingen, Germany.
Pancreas. 1992;7(6):719-25. doi: 10.1097/00006676-199211000-00014.
In 10 dogs with pancreatic fistulas, we studied the effect of extrinsic pancreatic innervation and atropine on protein and bicarbonate secretion and cholecystokinin (CCK) release after intraduodenal perfusion with HCl. Before and after extrinsic denervation of the pancreas, the dogs were given 0.05 M HCl in increasing doses (1.5-48 mmol/h). Tests were repeated with atropine. Increasing doses of HCl resulted in a dose-dependent release of protein and bicarbonate output in both the intact and the denervated pancreas. However, pancreatic denervation significantly decreased pancreatic secretion in response to low loads but not to high loads of HCl. HCl-stimulated CCK release was not altered by pancreatic denervation. In the intact pancreas, atropine significantly reduced bicarbonate and protein response to low loads but not to high doses of HCl. In the denervated gland, atropine had no further inhibitory effect on exocrine pancreatic secretion. Furthermore, atropine showed no influence on HCl-stimulated CCK release under either condition.
在10只患有胰瘘的狗身上，我们研究了胰腺外在神经支配和阿托品对十二指肠内灌注盐酸后蛋白质和碳酸氢盐分泌以及胆囊收缩素（CCK）释放的影响。在胰腺进行外在去神经支配前后，给狗给予递增剂量（1.5 - 48 mmol/h）的0.05 M盐酸。用阿托品重复进行试验。递增剂量的盐酸导致完整胰腺和去神经胰腺中蛋白质和碳酸氢盐的释放呈剂量依赖性增加。然而，胰腺去神经支配显著降低了胰腺对低剂量盐酸负荷的分泌反应，但对高剂量盐酸负荷的分泌反应没有影响。盐酸刺激的CCK释放不受胰腺去神经支配的影响。在完整胰腺中，阿托品显著降低了对低剂量盐酸负荷的碳酸氢盐和蛋白质反应，但对高剂量盐酸则没有影响。在去神经的腺体中，阿托品对外分泌性胰腺分泌没有进一步的抑制作用。此外，在两种情况下，阿托品对盐酸刺激的CCK释放均无影响。
