PAYNE J R, ROBINSON B R
Calif Med. 1962 May;96(5):330-4.
Phosphate insecticide use is increasing as is concomitant human poisoning. Home insecticide bomb as well as agricultural, crop contamination and suicidal exposure are noted. Clinical poisoning may be chronic and severe. It may follow long exposure or short exposure with heavy dosages. Manifestations are those of excessive cholinergic activity.Adequate laboratory means for early, rapid diagnosis and screen testings are available.PAM is a valuable agent for this type of poisoning and is a much more adequate and complete antidote than atropine. It is available (under certain restrictive conditions presently). It is being widely used elsewhere in the world but with limited education and use in this country. Morbidity and mortality continue at a rate that could probably be corrected. Case reports, describing the use of this antidote in our hands, are included. Government and industry responsibility as well as physician education must be more clearly defined in prevention, recognition and treatment in what is often a life threatening situation.
随着人类中毒事件的增加，有机磷杀虫剂的使用也在增多。家庭用杀虫弹以及农业、作物污染和自杀性接触等情况均有记录。临床中毒可能是慢性且严重的。它可能发生在长期接触或短时间大量接触之后。其表现为胆碱能活性亢进。有足够的实验室手段用于早期、快速诊断和筛查检测。解磷定（PAM）是这类中毒的有效药物，是比阿托品更充分、更完善的解毒剂。它目前在某些限制条件下可获取。它在世界其他地方被广泛使用，但在我国的应用教育和使用有限。发病率和死亡率仍维持在一个或许可以纠正的水平。本文包含了描述我们使用这种解毒剂的病例报告。在这种常常危及生命的情况下，政府、行业的责任以及医生的教育在预防、识别和治疗方面必须得到更明确的界定。
