Stricker-Krongrad A, Beck B, Nicolas J P, Burlet C
INSERM U-308, MRCA, Equipe de Neurobiologie et Physiologie Expérimentales, Nancy, France.
Pharmacol Biochem Behav. 1992 Nov;43(3):881-6. doi: 10.1016/0091-3057(92)90421-b.
Monosodium glutamate (MSG) is known as a neurotoxic molecule when injected neonatally in rats, where it produces a marked decrease in food intake and an increase in adipose tissue mass. But, in adult rats subcutaneous injections of MSG produce a small, dose-dependent increase in food intake. It is not known if this action is centrally or systemically mediated. Therefore, the feeding pattern of adult rats injected intracerebroventricularly with MSG was measured. Seven days after installation of a cannula in the right lateral ventricle, rats were injected either with artificial cerebrospinal fluid or twice with 3 mg/brain MSG within a 3-day interval. The feeding pattern was recorded via a complete computerized system during 24 h. Feeding behavior was significantly modified by MSG treatments. These effects were observed immediately after drug injections, that is, upon the first meal, as well as during the 24 h that followed. For the first meal, modifications in meal size (+285%; p = 0.0001), meal duration (x10; p = 0.0005), postmeal interval (x4; p = 0.0005), and the satiety ratio (-50%; p = 0.01) were observed. During the 24-h postinjection period, modifications in meal number (-3; p = 0.0007), total amount of food eaten (+21%,; p = 0.007), time spent eating (+40%; p = 0.007), meal duration (+53%; p = 0.005), and meal size (+44%; p = 0.01) were noted. When the two MSG injections were compared, differences were also noted. For the first meal, postmeal interval (-50%; p < 0.005) and satiety ratio (-50%; p < 0.005) were decreased after the second injection.(ABSTRACT TRUNCATED AT 250 WORDS)
当新生大鼠被注射味精（MSG）时，味精被认为是一种神经毒性分子，它会使大鼠的食物摄入量显著减少，脂肪组织量增加。但是，在成年大鼠中，皮下注射味精会使食物摄入量出现小幅度的、剂量依赖性的增加。目前尚不清楚这种作用是由中枢介导还是全身介导。因此，对脑室内注射味精的成年大鼠的进食模式进行了测量。在右侧脑室植入套管7天后，大鼠被注射人工脑脊液，或者在3天内分两次每次注射3毫克/脑的味精。通过完整的计算机系统记录24小时内的进食模式。味精处理显著改变了进食行为。这些影响在药物注射后立即观察到，即在第一餐时，以及随后的24小时内。对于第一餐，观察到餐量增加（+285%；p = 0.0001）、进餐持续时间增加（×10；p = 0.0005）、餐后间隔增加（×4；p = 0.0005）和饱腹感比率降低（-50%；p = 0.01）。在注射后24小时内，观察到进餐次数减少（-3；p = 0.0007）、进食总量增加（+21%；p = 0.007）、进食时间增加（+40%；p = 0.007）、进餐持续时间增加（+53%；p = 0.005）和餐量增加（+44%；p = 0.01）。当比较两次味精注射时，也发现了差异。对于第一餐，第二次注射后餐后间隔缩短（-50%；p < 0.005），饱腹感比率降低（-50%；p < 0.005）。（摘要截取自250字）
