PRICE W H, MATANOWSKI G, PREWER A, REACTOR L
J Gen Physiol. 1962 Mar;45(4)Pt 2(4):205-21. doi: 10.1085/jgp.45.4.205.
Chromatographic separations on DEAE cellulose have been carried out on the seromucoid fraction from forty-one normal individuals and twenty-three patients horpitalized with unilateral pneumococcal pneumonia. During the acute stages of their illness, all twenty-three patients showed a very marked difference in their seromucoid pattern as contrasted to the control group, both groups being comparable in age, sex, and race. As the patients recovered, their seromucoid patterns returned to that of the control group. Three patients with bilateral pneumococcal pneumonia showed seromucoid patterns similar to those of the twenty-three patients with unilateral pneumococcal pneumonia. Five individuals with viral pneumonia showed a seromucoid pattern similar to those observed in patients with pneumococcal pneumonia. The data suggested that the seromucoid pattern observed in pneumonia depended upon the stage of the disease of the patient, different patterns being observed during the acute, convalescent, and complete recovery stages. Each stage showed a characteristic pattern. The seromucoid pattern of seven patients with acute leukemia differed from that of the control groups and also differed from that observed in patients with pneumonia. Five individuals with chronic lymphocytic leukemia showed seromucoid patterns which could not be distinguished from those of the control group in spite of the fact that all showed clinical signs of disease at the time the blood sample was drawn for fractionation.
已对41名正常个体以及23名因单侧肺炎球菌肺炎住院的患者的血清类粘蛋白组分进行了DEAE纤维素柱色谱分离。在疾病的急性期，所有23名患者的血清类粘蛋白图谱与对照组相比均有非常显著的差异，两组在年龄、性别和种族方面具有可比性。随着患者康复，他们的血清类粘蛋白图谱恢复到对照组的水平。3名双侧肺炎球菌肺炎患者的血清类粘蛋白图谱与23名单侧肺炎球菌肺炎患者的图谱相似。5名病毒性肺炎患者的血清类粘蛋白图谱与肺炎球菌肺炎患者中观察到的图谱相似。数据表明，肺炎中观察到的血清类粘蛋白图谱取决于患者疾病的阶段，在急性期、恢复期和完全康复期观察到不同的图谱。每个阶段都显示出特征性图谱。7名急性白血病患者的血清类粘蛋白图谱与对照组不同，也与肺炎患者中观察到的图谱不同。5名慢性淋巴细胞白血病患者的血清类粘蛋白图谱与对照组无法区分，尽管在采集血样进行分离时所有患者均表现出疾病的临床症状。
