Herbst H, Milani S, Heinrichs O, Schuppan D
Institut für Pathologie, Klinikum Steglitz, Freie Universität Berlin, BRD.
Z Gastroenterol. 1992 Mar;30 Suppl 1:21-8.
The cellular localization of expression of various genes activated during the course of liver fibrosis and regeneration was studied by immunohistology and in situ hybridization in rat and human liver tissues. Mesenchymal cells proved to be the principal sources of extracellular matrix proteins and of fibrogenic growth factors, whereas the collagenase-activating protease transin/stromelysin gene was transcribed in parenchymal cells as well. Fibrogenesis by the mesenchymal compartment appears to be balanced by fibrolysis controlled by parenchymal cell functions. Continuous parenchymal damage may thus disrupt this balance between fibrogenesis and fibrolysis, resulting in fibrosis.
通过免疫组织学和原位杂交技术，对大鼠和人类肝脏组织中肝纤维化和再生过程中激活的各种基因的表达细胞定位进行了研究。间充质细胞被证明是细胞外基质蛋白和促纤维化生长因子的主要来源，而胶原酶激活蛋白酶转胶酶/基质溶解素基因也在实质细胞中被转录。间充质部分的纤维化似乎由实质细胞功能控制的纤维溶解所平衡。因此持续的实质损伤可能会破坏纤维化和纤维溶解之间的这种平衡，导致纤维化。
