Coccia G, Bortolotti M, Michetti P, Dodero M
Department of Gastroenterology, Galliera Hospital Genova, Italy.
Am J Gastroenterol. 1992 Dec;87(12):1705-8.
This study was carried out to demonstrate the possible return of esophageal peristalsis in patients affected by esophageal achalasia chronically treated with sublingual nifedipine and to investigate which parameters are correlated with the return of peristalsis. Thirty-two patients were treated with sublingual nifedipine 10-20 mg taken 30 min before meals. A clinical and manometric evaluation was performed before and after 6 months of therapy. Before treatment, in no patient was peristaltic activity recorded. After 6 months, peristalsis was observed in six patients. In this group, no pretreatment manometric parameter was different from that of the remaining achalasic patients; only the clinical history of dysphagia was significantly shorter (p < 0.001) and the esophageal diameter significantly less (p < 0.001). In conclusion, chronic treatment with sublingual nifedipine can induce a return of esophageal peristalsis in patients with a short clinical history of disease and slightly dilated esophagus.
本研究旨在证明长期接受舌下含服硝苯地平治疗的贲门失弛缓症患者食管蠕动功能可能恢复，并探究哪些参数与蠕动功能恢复相关。32例患者在饭前30分钟舌下含服10 - 20毫克硝苯地平。在治疗6个月前后进行了临床和测压评估。治疗前，所有患者均未记录到蠕动活动。6个月后，6例患者观察到蠕动。在这组患者中，治疗前的测压参数与其余失弛缓症患者无差异；只有吞咽困难的临床病史显著较短（p < 0.001），食管直径显著较小（p < 0.001）。总之，舌下含服硝苯地平的长期治疗可使疾病临床病史较短且食管轻度扩张的患者食管蠕动功能恢复。
