Ruah C B, Schachern P A, Paparella M M, Zelterman D
Department of Otolaryngology, School of Medicine, University of Minnesota, Minneapolis.
Arch Otolaryngol Head Neck Surg. 1992 Dec;118(12):1298-305. doi: 10.1001/archotol.1992.01880120024005.
The epidemiological nature of acquired cholesteatoma in children has shown that it occurs more often in the posterosuperior quadrant of the pars tensa and in the pars flaccida. This type of cholesteatoma is rarely seen before the age of 3 years, and serous otitis media is the most important risk factor for its occurrence. In an attempt to present a pathological rationale for these clinical findings, tympanic membranes from 11 temporal bones with purulent otitis media and 13 with serous otitis media were evaluated light microscopically and compared with 14 temporal bones without disease. Ages ranged from newborn to 3 years 6 months. The persistence of mesenchyme and greater inflammatory reaction observed in the pars flaccida and the posterosuperior quadrant of the pars tensa and changes in collagen and elastin observed in purulent otitis media and serous otitis media may represent a pathological rationale for the epidemiological nature of cholesteatoma in children.
儿童获得性胆脂瘤的流行病学特征表明，其更常发生于紧张部的后上象限及松弛部。这种类型的胆脂瘤在3岁前很少见，而浆液性中耳炎是其发生的最重要危险因素。为了对这些临床发现提供病理依据，对11例患有化脓性中耳炎的颞骨鼓膜和13例患有浆液性中耳炎的颞骨鼓膜进行了光镜评估，并与14例无疾病的颞骨进行了比较。年龄范围从新生儿到3岁6个月。在松弛部和紧张部的后上象限观察到的间充质持续存在和更强的炎症反应，以及在化脓性中耳炎和浆液性中耳炎中观察到的胶原蛋白和弹性蛋白的变化，可能代表了儿童胆脂瘤流行病学特征的病理依据。
