Guilbaud Olivier, Corcos Maurice, Hjalmarsson Linnea, Loas Gwenolé, Jeammet Philippe
Département de Psychiatrie de l'Adolescent et de l'Adulte Jeune, IMM, 42 Bd Jourdan, 75014, Paris, France.
Biomed Pharmacother. 2003 Sep;57(7):292-5. doi: 10.1016/s0753-3322(03)00085-4.
The term "alexithymia" was coined by Sifneos. It is characterised by a lack of words to express emotion (a: absence of; lexi: words; thymia: emotions, affects). Its characteristics were suggested to occur more frequently in individuals with so-called "psychosomatic disorders", but this is still a matter of controversy. Here we review the psychosomatic network of alexithymia, i.e. the immune and physiological correlates of alexithymia. Some studies suggest that inaccuracy in recognising emotional states, or the way of coping with negative emotions, may influence immune function. Alexithymia is associated with higher tonic baseline levels of sympathetic activity and lower sympathetic reactivity during acute stress. Few studies have reported a diminished immune-mediated cellular response in alexithymics with oversecretion of glucocorticoids. We hypothesise that alexithymic subjects may suffer from unnoticed chronic stress with physiological and endocrine and immune consequences. Alexithymia may skew the Th-1/Th-2 balance toward Th-2 dominant immunity and lower cell-mediated (Th-1) immune response and may increase an individual's risk for stress-related disorder.
“述情障碍”一词由西夫neos创造。它的特征是缺乏表达情感的词汇（a：缺乏；lexi：词汇；thymia：情感、情绪）。有人认为其特征在患有所谓“心身疾病”的个体中更频繁出现，但这仍是一个有争议的问题。在此，我们回顾述情障碍的心身网络，即述情障碍的免疫和生理关联。一些研究表明，识别情绪状态的不准确，或应对负面情绪的方式，可能会影响免疫功能。述情障碍与急性应激期间交感神经活动的较高静息基线水平和较低交感神经反应性相关。很少有研究报告，在糖皮质激素分泌过多的述情障碍患者中免疫介导的细胞反应减弱。我们假设，述情障碍患者可能遭受未被察觉的慢性应激，从而产生生理、内分泌和免疫后果。述情障碍可能会使Th-1/Th-2平衡偏向Th-2主导的免疫，降低细胞介导（Th-1）的免疫反应，并可能增加个体患应激相关障碍的风险。
