Oniki T, Hashimoto Y, Shimizu S, Kakuta T, Yajima M, Numano F
Third Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, Japan.
Br Heart J. 1992 Oct;68(4):425-9. doi: 10.1136/hrt.68.10.425.
To investigate the effects of heart rate on the Doppler measurements of left ventricular function and to determine the normal pattern of rate dependency.
University hospital specialising in internal medicine.
14 healthy male volunteers 10 of whom were studied.
Transoesophageal atrial pacing.
At paced rates of 70, 80, and 90 ppm the ratio of early to late peak transmitral flow velocity (E/A) was 1.97 (0.28), 1.49 (0.21), and 0.95 (0.11) respectively; the ratio of early to late time-velocity integrals of transmitral flow (Ei/Ai) was 3.03 (0.51), 2.11 (0.24), and 1.14 (0.30) respectively; and the atrial filling fraction (AFF) was 0.17 (0.03), 0.21, (0.04), and 0.24 (0.04) (mean (SD)).
Heart rate showed a linear correlation with E/A (r2 = 0.806), Ei/Ai (r2 = 0.838), and AFF (r2 = 0.343). Neither the peak aortic flow velocity or the mean aortic flow acceleration showed significant changes during pacing at rates of 70, 80, 90, and 100 ppm.
E/A and Ei/Ai can be expected to decrease by 0.5 and 0.9 for each increase of 10 beats/min in heart rate. Knowledge of this relation may be useful for the development of algorithms to correct for heart rate when diastolic function is assessed.
研究心率对左心室功能多普勒测量的影响，并确定心率依赖性的正常模式。
一所专门从事内科的大学医院。
14名健康男性志愿者，其中10名接受了研究。
经食管心房起搏。
在起搏频率为70、80和90次/分钟时，二尖瓣血流早期与晚期峰值流速之比（E/A）分别为1.97（0.28）、1.49（0.21）和0.95（0.11）；二尖瓣血流早期与晚期时间-流速积分之比（Ei/Ai）分别为3.03（0.51）、2.11（0.24）和1.14（0.30）；心房充盈分数（AFF）分别为0.17（0.03）、0.21（0.04）和0.24（0.04）（均值（标准差））。
心率与E/A（r2 = 0.806）、Ei/Ai（r2 = 0.838）和AFF（r2 = 0.343）呈线性相关。在70、80、90和100次/分钟的起搏频率下，主动脉峰值流速或平均主动脉血流加速度均未出现显著变化。
心率每增加10次/分钟，E/A和Ei/Ai预计分别降低0.5和0.9。了解这种关系可能有助于开发在评估舒张功能时校正心率的算法。
