Olinescu A, Olinescu E
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1977 Jul-Sep;22(3):179-86.
Impuber females of the RAP, Swiss, Albino-Rosso, NRMI and C57Bl mice strains were inoculated by intrauterine route with E. coli O55B5, following up the mortality rate, dissemination and persistence of the bacilli in different organs, the onest of possible lesions in the urinary and genital tract, the reproduction capacity and frequency of coli diarrhea in the progeny. The C57Bl, NRMI and H strains were more sensitive, and the RAP, Swiss and Albino-Rosso more resistent to the lethal effect of the intraperitoneal inoculations. Intrauterine inoculation revealed no significant difference in the susceptibility of the animal strains, the mortality rate being virtually nil even when doses much higher than those inoculated by i.p. route were used, except for C57Bl mice in which lethal cases were recorded also after intrauterine inoculation. E. coli was isolated from the liver and sporadically from the kidneys and urinary bladder up to 14 ways after i.p. inoculation. After intrauterine inoculation E. coli was isolated from the uterus up to 30 days, and sporadically from the kidneys and urinary bladder, but not from the liver. In this case, too, the C57Bl mice were the exception, E. coli benig found in the liver after both i.p. and intrauterine inoculation. The latter inoculation did not influence the reproduction capacity of the females or the appearance of epizootic diarrhea in the progeny.
将RAP、瑞士、白化-罗索、NRMI和C57Bl小鼠品系的未成年雌性小鼠经子宫内途径接种大肠杆菌O55B5，随后观察死亡率、细菌在不同器官中的传播和持续存在情况、泌尿生殖道可能出现的病变、繁殖能力以及子代中大肠杆菌腹泻的发生率。C57Bl、NRMI和H品系更敏感，而RAP、瑞士和白化-罗索品系对腹腔内接种的致死作用更具抵抗力。子宫内接种显示各动物品系的易感性无显著差异，即使使用远高于经腹腔途径接种的剂量，死亡率实际上也为零，但C57Bl小鼠在子宫内接种后也有致死病例记录。经腹腔接种后，在长达14天的时间里可从肝脏分离出大肠杆菌，偶尔也可从肾脏和膀胱分离出。经子宫内接种后，在长达30天的时间里可从子宫分离出大肠杆菌，偶尔也可从肾脏和膀胱分离出，但从肝脏中未分离出。同样，在这种情况下，C57Bl小鼠也是例外，经腹腔和子宫内接种后均在肝脏中发现了大肠杆菌。后一种接种方式不影响雌性小鼠的繁殖能力或子代中流行性腹泻的出现。
