伤寒沙门氏菌血清型伤寒杆菌的IVB型菌毛与囊性纤维化跨膜传导调节因子结合。
The type IVB pili of Salmonella enterica serovar Typhi bind to the cystic fibrosis transmembrane conductance regulator.
作者信息
Tsui Inez S M, Yip Cecilia M C, Hackett Jim, Morris Christina
机构信息
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
出版信息
Infect Immun. 2003 Oct;71(10):6049-50. doi: 10.1128/IAI.71.10.6049-6050.2003.
Salmonella enterica serovar Typhi expresses type IVB pili. We show that the prePilS protein (the soluble precursor form of the structural pilin) interacts with a 15-mer peptide representing the first extracellular domain of the cystic fibrosis transmembrane conductance regulator (CFTR), a recognized human epithelial cell receptor for serovar Typhi (G. B. Pier et al., Nature 393:79-82, 1998). This indicates that after mediating bacterial self-association (C. Morris et al., Infect. Immun. 71:1141-1146, 2003), the pili then act to attach the bacterial clumps to CFTR in the membrane of gut epithelial cells. These sequential type IVB pilus-mediated events cannot be performed by (for example) S. enterica serovar Typhimurium, which may explain why only serovar Typhi causes epidemics of enteric fever in humans.
伤寒沙门氏菌血清型伤寒杆菌表达IVB型菌毛。我们发现，前菌毛蛋白S（结构菌毛蛋白的可溶性前体形式）与一段15聚体肽相互作用，该肽段代表囊性纤维化跨膜传导调节因子（CFTR）的第一个细胞外结构域，CFTR是公认的伤寒杆菌血清型的人类上皮细胞受体（G. B. Pier等人，《自然》393:79 - 82，1998年）。这表明在介导细菌自我聚集后（C. Morris等人，《感染与免疫》71:1141 - 1146，2003年），菌毛随后将细菌团块附着于肠道上皮细胞膜中的CFTR。这些由IVB型菌毛介导的连续事件不能由（例如）鼠伤寒沙门氏菌血清型来完成，这可能解释了为什么只有伤寒杆菌血清型会在人类中引起伤寒流行。
Zotero 插件