Department of Medical Microbiology and Immunology, University of California, Davis School of Medicine, Davis, California 95616.
Cold Spring Harb Perspect Med. 2013 Dec 1;3(12):a010041. doi: 10.1101/cshperspect.a010041.
Most pathogens are able to infect multiple hosts but some are highly adapted to a single-host species. A detailed understanding of the basis of host specificity can provide important insights into molecular pathogenesis, the evolution of pathogenic microbes, and the potential for pathogens to cross the species barrier to infect new hosts. Comparative genomics and the development of humanized mouse models have provided important new tools with which to explore the basis of generalism and specialism. This review will examine host specificity of bacterial pathogens with a focus on generalist and specialist serovars of Salmonella enterica.
大多数病原体能够感染多种宿主，但有些则高度适应单一宿主物种。详细了解宿主特异性的基础可以为分子发病机制、病原微生物的进化以及病原体跨越物种屏障感染新宿主的潜力提供重要的见解。比较基因组学和人源化小鼠模型的发展为探索普遍性和特殊性的基础提供了重要的新工具。本文综述了细菌病原体的宿主特异性，重点关注沙门氏菌属的普遍血清型和特异血清型。
