Atterhög J H, Dunér H, Pernow B
Am J Med. 1976 May 31;60(6):872-6. doi: 10.1016/0002-9343(76)90907-4.
Ten patients, mean age 48 years, with essential hypertension of stage I and II according to the WHO classification, were studied at rest and during work before and after an average of two and 16 months of oral treatment with the beta-adrenergic blocking agent, pindolol. The pindolol treatment caused a significant decrease in the systemic systolic and diastolic blood pressure, both at rest and during work. Three mechanisms seem to be involved in the antihypertensive effect of pindolol: (1) a negative chronotropic effect on the heart, (2) a decrease in peripheral vascular resistance, and (3) an increase in venous capacitance affecting the venous return. However, the significance of these mechanisms seems to differ when the situations after two months of treatment are compared with those after 16 months of treatment. In the beginning, a decrease in cardiac output seems to be the main cause of the lowering of the blood pressure; later, a decrease in systemic vascular resistance might be of greater importance.
根据世界卫生组织分类标准，选取了10名年龄平均为48岁、患有I期和II期原发性高血压的患者，在口服β - 肾上腺素能阻滞剂吲哚洛尔进行平均两个月和16个月治疗前后，分别于静息状态及工作期间进行研究。吲哚洛尔治疗使静息和工作时的全身收缩压和舒张压均显著降低。吲哚洛尔的降压作用似乎涉及三种机制：(1) 对心脏的负性变时作用；(2) 外周血管阻力降低；(3) 静脉容量增加影响静脉回流。然而，将治疗两个月后的情况与治疗16个月后的情况相比较时，这些机制的重要性似乎有所不同。开始时，心输出量降低似乎是血压降低的主要原因；后期，全身血管阻力降低可能更为重要。
