Mehrabian Margarete, Allayee Hooman
Departments of Medicine and Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095-1679, USA.
Curr Opin Lipidol. 2003 Oct;14(5):447-57. doi: 10.1097/00041433-200310000-00005.
5-Lipoxygenase (5LO) was recently identified as a gene that makes an important contribution to atherosclerosis in mice and humans, but the underlying mechanism(s) remains unknown.
Studies of the 5LO pathway in other disease areas suggest that 5LO could contribute to atherosclerosis at different levels, such as lesion initiation, growth and cellular proliferation within the lesion, and/or destabilization of plaques that can lead to their rupture.
Recent advances in our understanding of how 5LO is involved in the atherosclerotic process will have important implications for diagnostic and therapeutic strategies in the future.
5-脂氧合酶（5LO）最近被确定为一种对小鼠和人类动脉粥样硬化有重要影响的基因，但其潜在机制仍不清楚。
对5LO途径在其他疾病领域的研究表明，5LO可能在不同层面促进动脉粥样硬化，如病变起始、病变内生长和细胞增殖，和/或导致斑块破裂的斑块不稳定。
我们对5LO如何参与动脉粥样硬化过程的最新认识进展将对未来的诊断和治疗策略产生重要影响。
