慢性胆囊炎中的微卫星不稳定性表明胆囊癌发生处于早期阶段。

Microsatellite instability in chronic cholecystitis is indicative of an early stage in gallbladder carcinogenesis.

作者信息

Yanagisawa Nobuyuki, Mikami Tetuo, Yamashita Kazuya, Okayasu Isao

机构信息

Dept of Pathology, Kitasato University, School of Medicine, Kitasato 1-15-1, Sagamihara, Kanagawa 228-8555, Japan.

出版信息

Am J Clin Pathol. 2003 Sep;120(3):413-7. doi: 10.1309/BYRN-ALP8-GN63-DHAJ.

DOI:10.1309/BYRN-ALP8-GN63-DHAJ

PMID:14502806

Abstract

The study of microsatellite instability (MSI) in cases of severe chronic cholecystitis and gallbladder carcinomas, to cast light on its significance for tumorigenesis, revealed MSI in 9 (30%) of 30 cases of cholecystitis and 7 (41%) of 17 carcinomas, respectively. In addition, 5 (33%) of 15 samples of background mucosa of carcinoma were positive. Respective figures for loss of heterozygosity were 3 (10%) of 30 cases of cholecystitis, 6 (35%) of 17 carcinomas, and 1 (7%) of 15 samples of adjacent nonneoplastic mucosa. No correlation was observed among MSI state, immunohistochemical hMLH1 or hMSH2 expression, and any clinicopathologic factors. MSI was observed not only in gallbladder tumors but also in severe chronic cholecystitis and background mucosa, suggesting that it may have an important role in early-stage gallbladder carcinogenesis.

摘要

对严重慢性胆囊炎和胆囊癌病例中的微卫星不稳定性（MSI）进行研究，以阐明其在肿瘤发生中的意义，结果显示，30例胆囊炎病例中有9例（30%）存在MSI，17例癌症病例中有7例（41%）存在MSI。此外，15例癌旁黏膜样本中有5例（33%）呈阳性。杂合性缺失的相应数据分别为：30例胆囊炎病例中有3例（10%），17例癌症病例中有6例（35%），15例相邻非肿瘤性黏膜样本中有1例（%）。未观察到MSI状态、免疫组化hMLH1或hMSH2表达与任何临床病理因素之间存在相关性。MSI不仅在胆囊肿瘤中被观察到，在严重慢性胆囊炎和癌旁黏膜中也被观察到，这表明它可能在胆囊癌发生的早期阶段起重要作用。