Kirkpatrick Brian, Messias Nidia C, Conley Robert R, Roberts Rosalinda C
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
J Nerv Ment Dis. 2003 Sep;191(9):563-7. doi: 10.1097/01.nmd.0000087181.61164.e1.
An increased density of neurons in the white matter of the neocortex has been found in schizophrenia, and the original reports suggested this abnormality was restricted to a subgroup of patients. In a study of the inferior parietal cortex, we found that deficit schizophrenia subjects, but not nondeficit subjects, had an increased density of ICWMs. We extended that finding by comparing the density of microtubule-associated protein 2-immunoreactive ICWMs in deficit schizophrenia (N = 3), nondeficit schizophrenia (N = 4), and control (N = 5) subjects, using postmortem tissue from the dorsolateral prefrontal cortex (Brodmann area 46). The deficit group differed significantly from the other two groups; the respective mean (SD) density values for the deficit, nondeficit, and control groups were 1.27 (.10),.53 (.39), and.76 (.20) cells per 10-6 cubic microns. These group differences provide further evidence that deficit and nondeficit schizophrenia differ in their pathophysiology.
在精神分裂症患者中，已发现新皮质白质中神经元密度增加，最初的报告表明这种异常仅限于部分患者亚组。在一项对顶下小叶皮质的研究中，我们发现，缺损型精神分裂症患者而非非缺损型患者的内层锥体细胞白质密度增加。我们通过比较缺损型精神分裂症患者（N = 3）、非缺损型精神分裂症患者（N = 4）和对照组（N = 5）的微管相关蛋白2免疫反应性内层锥体细胞白质密度，扩展了这一发现，所用组织为背外侧前额叶皮质（布罗德曼46区）的尸检组织。缺损组与其他两组有显著差异；缺损组、非缺损组和对照组每10-6立方微米的平均（标准差）密度值分别为1.27（.10）、.53（.39）和.76（.20）个细胞。这些组间差异进一步证明，缺损型和非缺损型精神分裂症在病理生理学上存在差异。
