Yamasue Hidenori, Iwanami Akira, Hirayasu Yoshio, Yamada Haruyasu, Abe Osamu, Kuroki Noriomi, Fukuda Rin, Tsujii Kazuo, Aoki Shigeki, Ohtomo Kuni, Kato Nobumasa, Kasai Kiyoto
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan.
Psychiatry Res. 2004 Sep 15;131(3):195-207. doi: 10.1016/j.pscychresns.2004.05.004.
Functional and structural abnormalities of the anterior cingulate gyrus (ACG) in patients with schizophrenia have been repeatedly reported. However, one remaining issue is whether gray matter volume reduction in ACG exists to an extent comparable with, or even in excess of, that in other prefrontal and temporolimbic regions. High-spatial-resolution magnetic resonance imaging was performed on patients with schizophrenia (n=27) and on age-, gender-, and parental socioeconomic-status-matched healthy control subjects (n=27). After the gray and white matter were semiautomatically segmented, whole prefrontal and temporal lobes were manually parceled into 15 subregions-by-two hemispheres (30 regions of interest) constituting seven prefrontal gray matter regions, six temporal gray matter regions, the prefrontal white matter, and the temporal white matter. Compared with healthy subjects, schizophrenic patients showed significant gray matter volume reduction in the bilateral ACG, this being the largest effect size (left, 0.84; right, 0.56) among all the regions examined. There were also significant gray matter volume reductions in the bilateral posterior STG, bilateral inferior frontal gyrus, left posterior amygdala-hippocampal complex (mostly hippocampus), and the left insula. These results suggest that gray matter volume reductions in the ACG are prominent among prefrontal and temporolimbic regions in patients with schizophrenia. These findings indicate the importance of ACG abnormalities in the pathophysiology of schizophrenia.
精神分裂症患者前扣带回皮质（ACG）的功能和结构异常已被多次报道。然而，一个尚存的问题是，ACG灰质体积减少的程度是否与其他前额叶和颞叶边缘区域相当，甚至超过这些区域。对27例精神分裂症患者以及年龄、性别和父母社会经济地位相匹配的27名健康对照者进行了高空间分辨率磁共振成像检查。在对灰质和白质进行半自动分割后，将整个前额叶和颞叶手动划分为15个亚区域（两个半球各15个），共构成7个前额叶灰质区域、6个颞叶灰质区域、前额叶白质和颞叶白质。与健康受试者相比，精神分裂症患者双侧ACG灰质体积显著减少，这是所有检查区域中效应量最大的（左侧为0.84；右侧为0.56）。双侧颞上回后部、双侧额下回、左侧后杏仁核 - 海马复合体（主要是海马体）以及左侧脑岛的灰质体积也有显著减少。这些结果表明，在精神分裂症患者中，ACG的灰质体积减少在前额叶和颞叶边缘区域中较为突出。这些发现表明ACG异常在精神分裂症病理生理学中的重要性。
