Yilmazer Mehmet, Kurtay Gulay, Sonmezer Murat, Akar Nejat
Department of Obstetrics and Gynecology, Afyon Kocatepe University School of Medicine, Afyon, Turkey.
Arch Gynecol Obstet. 2003 Oct;268(4):304-8. doi: 10.1007/s00404-002-0430-4. Epub 2002 Nov 7.
Factor V Leiden and prothrombin 20210 G-A mutations are independent risk factors for venous thrombosis. We studied the frequency of these mutations in 35 patients who had thromboembolic events during pregnancy and puerperium, and in 32 women who had a history of uncomplicated pregnancy, delivered either vaginally or by cesarean section, and did not have a past history of thromboembolism. Factor V Leiden mutation was present in 7 patients (20%) in the study group. Of these 7 patients, 1 was homozygote, whereas the remaining 6 were heterozygote for the mutation. Prothrombin 20210 G-A mutation was present in 2 patients (5.7%) in the study group. In the control group none of the 32 patients was positive for the factor V Leiden and prothrombin 20210 G-A mutations. Our findings indicate that the factor V Leiden mutation is an important risk factor for thromboembolic disease during pregnancy or puerperium.
凝血因子V莱顿突变和凝血酶原20210 G-A突变是静脉血栓形成的独立危险因素。我们研究了35例在妊娠和产褥期发生血栓栓塞事件的患者以及32例有正常妊娠史、经阴道或剖宫产分娩且既往无血栓栓塞病史的女性中这些突变的发生率。研究组中有7例患者（20%）存在凝血因子V莱顿突变。在这7例患者中，1例为纯合子，其余6例为杂合子。研究组中有2例患者（5.7%）存在凝血酶原20210 G-A突变。在对照组的32例患者中，凝血因子V莱顿突变和凝血酶原20210 G-A突变均为阴性。我们的研究结果表明，凝血因子V莱顿突变是妊娠或产褥期血栓栓塞性疾病的重要危险因素。
