Tskhovrebova Larissa, Trinick John
Astbury Centre for Structural Molecular Biology, and School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK.
Nat Rev Mol Cell Biol. 2003 Sep;4(9):679-89. doi: 10.1038/nrm1198.
In striated muscles, the rapid production of macroscopic levels of force and displacement stems directly from highly ordered and hierarchical protein organization, with the sarcomere as the elemental contractile unit. There is now a wealth of evidence indicating that the giant elastic protein titin has important roles in controlling the structure and extensibility of vertebrate muscle sarcomeres.
在横纹肌中,宏观水平的力和位移的快速产生直接源于高度有序且层次分明的蛋白质组织,其中肌节是基本的收缩单位。现在有大量证据表明,巨大的弹性蛋白肌联蛋白在控制脊椎动物肌肉肌节的结构和伸展性方面发挥着重要作用。