全身性缺氧和复氧对新生大鼠脑、肝、肺及血浆中谷胱甘肽氧化还原系统的影响。

The influence of systemic hypoxia and reoxygenation on the glutathione redox system of brain, liver, lung and plasma in newborn rats.

作者信息

Reuter A, Klinger W

机构信息

Department of Pediatrics, Friedrich Schiller University Jena, Germany.

出版信息

Exp Toxicol Pathol. 1992 Oct;44(6):339-43. doi: 10.1016/s0940-2993(11)80224-1.

DOI:10.1016/s0940-2993(11)80224-1

PMID:1450653

Abstract

The concentrations of reduced (GSH) and oxidized glutathione (glutathione disulfide, GSSG) in lung, liver, brain and plasma of newborn rats were investigated under the condition of reversible hypoxia. Brain and lung of newborn rats seem to be susceptible to reversible hypoxia. We found an increase in GSSG concentration after hypoxia in these organs. This alteration of the GSH-GSSG redox system was reversible within 2 hours of reoxygenation. A second increase in cerebral GSSG concentration after 4 hours of reoxygenation was connected with fasting during the experiment. In the liver we found a hypoxia dependent decrease in the GSH level, followed by a decrease in GSSG concentration. The increased GSSG concentrations in lung and brain are accompanied by an enhancement of plasma GSSG concentration.

摘要

在可逆性缺氧条件下，对新生大鼠肺、肝、脑及血浆中还原型谷胱甘肽（GSH）和氧化型谷胱甘肽（谷胱甘肽二硫化物，GSSG）的浓度进行了研究。新生大鼠的脑和肺似乎对可逆性缺氧敏感。我们发现缺氧后这些器官中GSSG浓度升高。谷胱甘肽氧化还原系统的这种变化在复氧2小时内是可逆的。复氧4小时后大脑GSSG浓度的再次升高与实验期间禁食有关。在肝脏中，我们发现谷胱甘肽水平因缺氧而降低，随后GSSG浓度也降低。肺和脑中升高的GSSG浓度伴随着血浆GSSG浓度的升高。