Kita M, Tong L J, Nakajima E, Yamada A, Sasaki O, Yamaguchi N, Kishida T, Imanishi J
Département de Microbiologie, Université Médicale de la Préfecture de Kyoto, Japan.
C R Seances Soc Biol Fil. 1992;186(1-2):156-63.
The HuIFN-alpha and beta genes were examined by the PCR method in the 11 human lymphoblastoid cell lines. The results showed that the homozygous deletion of HuIFN-alpha and beta genes was detected in 5 of 11 cell lines and in 5 of 11 cell lines, respectively. The deletions of both the HuIFN-alpha and beta genes were observed in 4 of 11 cell lines. One T cell leukemia cell line deleted only HuIFN-alpha gene, while the other T cell leukemia line deleted only HuIFN-beta gene. This suggests that the deletions of HuIFN-alpha and beta genes may be related the development of leukemia or lymphoma.
采用聚合酶链反应（PCR）方法检测了11个人类淋巴母细胞系中的人α干扰素（HuIFN-α）和β干扰素（HuIFN-β）基因。结果显示，分别在11个细胞系中的5个细胞系检测到HuIFN-α基因纯合缺失，在11个细胞系中的5个细胞系检测到HuIFN-β基因纯合缺失。在11个细胞系中的4个细胞系观察到HuIFN-α和β基因均缺失。一个T细胞白血病细胞系仅缺失HuIFN-α基因，而另一个T细胞白血病细胞系仅缺失HuIFN-β基因。这表明HuIFN-α和β基因的缺失可能与白血病或淋巴瘤的发生有关。
