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Synthesis and hypnotic-sedative activities of N-substituted uracil on mice.

作者信息

Maruyama Tokumi, Kozai Shigetada, Shimizu Tomomi, Kimura Toshiyuki, Watanabe Kazuhito, Yamamoto Ikuo

机构信息

School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka 882-8508, Japan.

出版信息

Nucleic Acids Res Suppl. 2003(3):25-6. doi: 10.1093/nass/3.1.25.

DOI:10.1093/nass/3.1.25
PMID:14510362
Abstract

N3-Phenacyl-N1-substituted uracils 3a-q were synthesized by introduction of substituents at the N1-position of N3-phenacyluracil 2, and their hypnotic and sedative activities were evaluated. Pharmacological activities of these N3-phenacyl-N1-substituted uracils were examined using hypnotic activity and synergistic effects with pentobarbital or diazepam for the hypnotic and sedative activities.

摘要

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