Structure and physicochemical properties of diastereomeric isomers of ApA.
作者信息
Urata Hidehito, Go Makiko, Hara Hisafumi, Akagi Masao
机构信息
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
出版信息
Nucleic Acids Res Suppl. 2003(3):41-2. doi: 10.1093/nass/3.1.41.
PMID:14510370
Abstract
Heterochiral ApAs (ALpAD and ADpAL) together with homochiral D-(ApA) and L-(ApA) were synthesized and their helical structures were investigated by using spectroscopic techniques. The results indicate that the chirality of the 3'-end residue is the primary determinant for the helical sense of adenylyl-(3'-5')-adenosine (ApA).
摘要
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