膦酸酯ApA类似物与聚（U）复合物的紫外光谱研究：预测寡核苷酸类似物性质的有前景的一步？

UV spectroscopy study on complexes of phosphonate ApA analogs with poly(U): promising step in prediction of oligonucleotide analog properties?

作者信息

Pressová M, Endová M, Toĉík Z, Liboska R, Rosenberg I

机构信息

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague.

出版信息

Bioorg Med Chem Lett. 1998 May 19;8(10):1225-30. doi: 10.1016/s0960-894x(98)00190-5.

DOI:10.1016/s0960-894x(98)00190-5

PMID:9871740

Abstract

The isopolar nonisosteric phosphonate analogs of ApA differing in the position of extra methylene group introduced into the sugar-phosphate backbone, featuring both possible 2',5'- and 3',5'- pairs as well as their conformationally restricted congeners, were investigated for their ability to form complexes with polyU. The results may lead to the specification of candidates for synthesis of novel oligonucleotides.

摘要

研究了ApA的等极性非等排膦酸酯类似物，这些类似物在引入糖磷酸主链的额外亚甲基位置上有所不同，具有可能的2',5'-和3',5'-对以及它们的构象受限同系物，考察了它们与聚U形成复合物的能力。这些结果可能有助于确定新型寡核苷酸合成候选物的具体情况。