Achmatowicz Michal, Hegedus Louis S, David Scott
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
J Org Chem. 2003 Oct 3;68(20):7661-6. doi: 10.1021/jo0301393.
A series of 4-substituted pyridine-capped 5,12-dioxocyclams was synthesized and fully characterized. The 4-substituent varied from electron-withdrawing groups (NO2, NO, CN) to electron-donating groups (NHCbz, NH2). The most versatile substituent was the 4-bromo group, which could be replaced by a variety of groups using Stille, Sonogashira, or Buchwald-Hartig palladium-catalyzed chemistry. Copper complexes of a majority of these capped dioxocyclams were synthesized and characterized as well.
合成了一系列4-取代吡啶封端的5,12-二氧杂环胺，并对其进行了全面表征。4-取代基从吸电子基团（NO2、NO、CN）到供电子基团（NHCbz、NH2）不等。最通用的取代基是4-溴基团，它可以通过Stille、Sonogashira或Buchwald-Hartig钯催化化学被各种基团取代。还合成并表征了这些封端二氧杂环胺中大多数的铜配合物。
