Graziani Edmund I, Overk Cassia R, Carter Guy T
Department of Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, USA.
J Nat Prod. 2003 Sep;66(9):1149-53. doi: 10.1021/np0301691.
Neutramycins B-G were purified from a historical sample of neutramycin in our antibiotic collection. The structures of the compounds were solved by 2D NMR spectroscopic analysis. Four of the compounds (2-5) are probable biosynthetic intermediates or shunt metabolites of neutramycin biosynthesis, while two (6, 7) are likely to be degradation products. Only one intermediate (5) showed weak Gram-positive activity.
中性霉素B - G是从我们抗生素库中一份历史样本的中性霉素中纯化得到的。这些化合物的结构通过二维核磁共振光谱分析得以解析。其中四种化合物（2 - 5）可能是中性霉素生物合成的生物合成中间体或旁路代谢产物，而另外两种（6, 7）可能是降解产物。只有一种中间体（5）表现出微弱的革兰氏阳性活性。
