Hardus Peter, Verduin Willem, Berendschot Tos, Postma Gina, Stilma Jan, van Veelen Cees
Department of Ophthalmology, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, the Netherlands.
Acta Ophthalmol Scand. 2003 Oct;81(5):459-65. doi: 10.1034/j.1600-0420.2003.00085.x.
To report the results of repeated electrophysiological and visual field examinations in patients with vigabatrin-associated visual field loss (VGB-VFL) and the relationship between these electrophysiological findings, the cumulative dose of vigabatrin and the extent of visual field loss.
Twenty-two eyes of 11 patients with VGB-VFL were studied. All patients underwent surgery for therapy-resistant epilepsy. Repeated electro-oculograms (EOGs) and flash electroretinograms (ERGs) were made and the cumulative dose of vigabatrin and the visual field loss were recorded after a period of 37-47 months.
The visual field loss was stable in patients who had stopped vigabatrin at the time of the first examination. There was a slight increase in VFL in patients who continued vigabatrin. During the second EOG and ERG, abnormalities in scotopic and photopic a-wave latencies and in scotopic b-wave amplitude were found in more than 50% of patients. Only b-wave latency became normal, while EOG, a-wave latency, a-wave amplitude and b-wave amplitude stayed abnormal. The amount of VFL and the cumulative dose of vigabatrin were statistically correlated with the b-wave amplitude, mainly photopic, found during the first and second examinations.
After 4 years, EOG, flash ERG and visual field loss had not improved in patients with VGB-VFL. The statistically significant correlation found during the first examination between the amount of VFL and the cumulative dose of vigabatrin with the (mainly photopic) b-wave amplitude remained constant.
报告vigabatrin相关视野缺损（VGB-VFL）患者重复进行电生理和视野检查的结果，以及这些电生理结果、vigabatrin累积剂量与视野缺损程度之间的关系。
研究11例VGB-VFL患者的22只眼。所有患者均接受了治疗难治性癫痫的手术。在37-47个月后进行重复眼电图（EOG）和闪光视网膜电图（ERG）检查，并记录vigabatrin的累积剂量和视野缺损情况。
首次检查时已停用vigabatrin的患者视野缺损稳定。继续使用vigabatrin的患者视野缺损略有增加。在第二次EOG和ERG检查中，超过50%的患者在暗视和明视a波潜伏期以及暗视b波振幅方面存在异常。只有b波潜伏期恢复正常，而EOG、a波潜伏期、a波振幅和b波振幅仍异常。视野缺损量和vigabatrin累积剂量与首次和第二次检查时发现的（主要是明视）b波振幅在统计学上相关。
4年后，VGB-VFL患者的EOG、闪光ERG和视野缺损均未改善。首次检查时发现的视野缺损量和vigabatrin累积剂量与（主要是明视）b波振幅之间的统计学显著相关性保持不变。
