Houston Rebecca J, Bauer Lance O, Hesselbrock Victor M
Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, MC-2103, Farmington, CT 06030-2103, USA.
Psychiatry Res. 2003 Sep 30;124(1):49-62. doi: 10.1016/s0925-4927(03)00074-x.
The present study evaluated the effects of depression and a family history of alcohol or substance dependence on P300 event-related potentials in young women aged 14 to 20 years. Of the 130 female subjects, 29 met DSM-III-R diagnostic criteria for a lifetime history of a Major Depressive Episode. Event-related electroencephalographic potentials were recorded from each subject while she performed a complex visual oddball task. Analyses indicated a decrement in P300 amplitude in the depressed group as compared to girls with no history of depression. No effects of family history of alcoholism or drug dependence were detected. Current source density analyses, utilizing a realistic head-shape boundary element model, indicated that the difference between the depressed and non-depressed groups was maximal in the right prefrontal region. These results provide further support for the notion that the cognitive difficulties associated with depression are subtle and best detected with sensitive neurophysiological indices, such as P300.
本研究评估了抑郁以及酒精或物质依赖家族史对14至20岁年轻女性P300事件相关电位的影响。在130名女性受试者中，29名符合DSM-III-R关于重度抑郁发作终生史的诊断标准。在每位受试者执行复杂视觉oddball任务时记录事件相关脑电图电位。分析表明，与无抑郁病史的女孩相比，抑郁组的P300波幅降低。未检测到酒精中毒或药物依赖家族史的影响。利用逼真的头部形状边界元模型进行的电流源密度分析表明，抑郁组和非抑郁组之间的差异在右前额叶区域最大。这些结果进一步支持了这样一种观点，即与抑郁相关的认知困难很细微，最好用敏感的神经生理指标（如P300）来检测。
