Shibata Annemarie, Zelivyanskaya Marina, Limoges Jenae, Carlson Kimberly A, Gorantla Santhi, Branecki Chad, Bishu Shrinivas, Xiong Huangui, Gendelman Howard E
Center for Neurovirology and Neurodegenerative Disorders and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 985215 Nebraska Medical Center, Omaha, NE 68198-5215, USA.
J Neuroimmunol. 2003 Sep;142(1-2):112-29. doi: 10.1016/s0165-5728(03)00253-4.
Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.
