George Timothy M, Bulsara Ketan R, Cummings Thomas J
Department of Pediatric Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA.
Pediatr Neurosurg. 2003 Nov;39(5):227-33. doi: 10.1159/000072866.
The embryopathy underlying tethering of the filum terminale is poorly understood. Knowledge of normal filum development is the foundation upon which to compare normal fila to fila from patients with tethered cord syndrome. Thirty-four fila from patients with tethered cord syndrome were immunostained with caudal neural tube developmental markers H4C4 (CD44), VIN-IS-53, AC4, FP3 and NOT1, and a panel of mature neuroglial, neural crest, epithelial and mesenchymal markers. H4C4 (CD44) and NOT1 exhibited significant alterations in immunoexpression in tethered fila compared to controls. The change in expression may be indicative of altered cell identity in the filum and constitute the predisposition to tethering.
终丝栓系综合征潜在的胚胎病变目前了解甚少。正常终丝发育的知识是将正常终丝与脊髓栓系综合征患者的终丝进行比较的基础。对34例脊髓栓系综合征患者的终丝进行免疫染色，使用尾侧神经管发育标志物H4C4（CD44）、VIN-IS-53、AC4、FP3和NOT1，以及一组成熟的神经胶质、神经嵴、上皮和间充质标志物。与对照组相比，H4C4（CD44）和NOT1在栓系终丝中的免疫表达出现了显著变化。表达的改变可能表明终丝中细胞特性发生了改变，并构成了栓系的易感性。
