Miserez André R, Clavaguera Florence, Monsch Andreas U, Probst Alphonse, Tolnay Markus
Cardiovascular Genetics, Institute of Biochemistry and Genetics, Department of Clinical-Biological Sciences, University of Basel, Basel, Switzerland.
Acta Neuropathol. 2003 Oct;106(4):363-6. doi: 10.1007/s00401-003-0742-x. Epub 2003 Aug 29.
Argyrophilic grain disease (AgD) is a four-repeat tauopathy that is almost exclusively restricted to allocortical areas. Progressive supranuclear palsy and corticobasal degeneration also show predominant deposition of four-repeat tau filaments, and are associated with the tau H1 haplotype. We investigated a possible association between AgD and the tau H1 haplotype. In AgD, no difference between the prevalence of the tau H1 haplotype or H1/H1 genotype was observed when compared to non-demented control cases. These data suggest that a dysfunction of the tau protein in AgD-in contrast to other four-repeat tauopathies-may arise irrespective of the genetic background regarding the tau H1 or H2 haplotypes.
嗜银颗粒病（AgD）是一种几乎仅局限于异皮质区域的四重复tau蛋白病。进行性核上性麻痹和皮质基底节变性也显示出四重复tau细丝的主要沉积，并与tau H1单倍型相关。我们研究了AgD与tau H1单倍型之间可能的关联。在AgD中，与非痴呆对照病例相比，未观察到tau H1单倍型或H1/H1基因型患病率的差异。这些数据表明，与其他四重复tau蛋白病不同，AgD中tau蛋白的功能障碍可能与tau H1或H2单倍型的遗传背景无关。
