Singh A B, Thomas T J, Singh M, Mann R A
Division of Nephrology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903.
Clin Immunol Immunopathol. 1992 Dec;65(3):242-6. doi: 10.1016/0090-1229(92)90153-f.
Intravenous injection of 5 x 10(7) C57BL/6 (B6) lymphocytes into adult (C57BL/6 x DBA/2)F1 recipient mice results in acute lethal graft-versus-host (ALGVH) disease. This disorder is characterized by anemia, a diminished number of splenocytes, impaired cytotoxicity (CTX) against third party alloantigen, and impaired natural killer cell (NK) activity. Parental anti-F1 CTX is critical to the induction of ALGVH disease, and CTX in general has been reported to be dependent upon the presence of the low molecular weight polyamines essential for cell growth and differentiation. We now report that DL-alpha-difluoromethylornithine, a specific inhibitor of polyamine biosynthesis, attenuates the clinical expression of disease in mice undergoing ALGVH disease.
向成年（C57BL/6×DBA/2）F1受体小鼠静脉注射5×10⁷个C57BL/6（B6）淋巴细胞会导致急性致死性移植物抗宿主（ALGVH）病。这种病症的特征是贫血、脾细胞数量减少、针对第三方同种异体抗原的细胞毒性（CTX）受损以及自然杀伤细胞（NK）活性受损。亲代抗F1 CTX对于ALGVH病的诱导至关重要，并且一般报道CTX依赖于细胞生长和分化所必需的低分子量多胺的存在。我们现在报道，多胺生物合成的特异性抑制剂DL-α-二氟甲基鸟氨酸可减轻发生ALGVH病的小鼠的疾病临床症状。
